Luxury hotels in Santorini promise extraordinary experiences that go far beyond the ordinary. Add to that a prime location, exclusive 5-star service, top-notch design and the finest amenities. Among the most popular luxury hotels in Santorini is the 5 star hotel La Perla Villas and Suites | Adults only in Oia. Also highly recommended are 5 star hotel Carpe Diem Santorini in Pyrgos Kallistis and 5 star hotel Katikies Hotel in Oia.